解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:INTRODUCTION:Chronic obstructive pulmonary disease is a progressive lung disease characterized by abnormal cellular responses to cigarette smoke, resulting in tissue destruction and airflow limitation. Autophagy is a fundamental cellular process that eliminates long-lived proteins and damaged organelles through lysosom...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-017-9997-1
更新日期:2017-06-01 00:00:00
abstract:BACKGROUND:Pulmonary arterial hypertension (PAH) is a deadly disease, and the molecular mechanism of PAH has not been clarified clearly. The objective of this study was to identify possible biomarkers and explore the potential mechanisms of Schistosoma-induced PAH. METHODS:GSE49114 RNA-Seq data developed from mouse wh...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-017-9999-z
更新日期:2017-06-01 00:00:00
abstract:OBJECTIVES:We evaluated the diagnostic value for pulmonary embolism (PE) of the True fast imaging with steady-state precession (TrueFISP) MRI, a method that allows the visualization of pulmonary vasculature without breath holding or intravenous contrast. METHODS:This is a prospective investigation including 93 patient...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-017-9975-7
更新日期:2017-04-01 00:00:00
abstract::Electronic noses (e-noses) are based on arrays of different sensor types that respond to specific features of an odorant molecule, mostly volatile organic compounds (VOCs). Differently from gas chromatography and mass spectrometry, e-noses can distinguish VOCs spectrum by pattern recognition. E-nose technology has suc...
journal_title:Lung
pub_type: 杂志文章,评审
doi:10.1007/s00408-017-9987-3
更新日期:2017-04-01 00:00:00
abstract:INTRODUCTION:The goal of our systematic review and meta-analysis is to examine the therapeutic effectiveness of bronchoscopic lung volume reduction (BLVR), and to compare it with medical management and lung volume reduction surgery. METHODS:Variables of interest were absolute change in FEV1, 6MWT, and SGRQ. Meta-analy...
journal_title:Lung
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s00408-016-9969-x
更新日期:2017-02-01 00:00:00
abstract:PURPOSE:The change in vital capacity from the seated to supine position (∆VC-supine) is used to screen for diaphragm dysfunction (DD), but some individuals are unable to tolerate the supine position. Since expiratory muscle function is often preserved in patients with isolated DD and inspiratory strength is reduced, th...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-016-9959-z
更新日期:2017-02-01 00:00:00
abstract:ABSTARCT:New anti-fibrotic agents for idiopathic pulmonary fibrosis (IPF) were approved based on the results of forced vital capacity (FVC) trends, although concerns were raised about the reliability of FVC as the only endpoint parameter. We hypothesized that IPF-specific multi-dimensional scores (Composite Physiologic...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-016-9963-3
更新日期:2017-02-01 00:00:00
abstract::Reports regarding smoking differences in α-klotho expression have provided conflicting results. In the current study we focused on the influence of smoking intensity to serum levels of the aging molecule α-klotho in healthy smokers. 40 middle aged healthy smokers without airway obstruction or restriction were selected...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-016-9944-6
更新日期:2017-02-01 00:00:00
abstract:PURPOSE:We investigated outcomes of patients hospitalized with community-acquired pneumonia (CAP) according to the changes in red cell distribution width (RDW). METHODS:For 980 adults, clinical characteristics, outcomes during hospitalization for CAP (transfer to the intensive care unit, treatment with mechanical vent...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-016-9942-8
更新日期:2016-12-01 00:00:00
abstract:INTRODUCTION:Hypoxia has been implicated in the pathogenesis of many inflammatory and fibrotic lung diseases. The effect of hypoxia on epithelial junction protein expression is yet to be fully elucidated but evidence suggests a protective role for the hypoxia-inducible transcription factor HIF-1 in stabilising occludin...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-016-9918-8
更新日期:2016-10-01 00:00:00
abstract:BACKGROUND:Recent studies have demonstrated non-inferiority of rivaroxaban when compared to warfarin for the treatment of pulmonary embolism and deep venous thrombosis. Analysis of data from the EINSTEIN trials has demonstrated that patients who received rivaroxaban had a shorter length of stay (LOS) compared to those ...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-016-9898-8
更新日期:2016-08-01 00:00:00
abstract:BACKGROUND:Survival implications of pre-transplant antibodies to human leukocyte antigens prior to lung transplantation (LTx) in adult cystic fibrosis (CF) patients are unknown. METHODS:Data from the United Network for Organ Sharing Registry (1987-2013) were used to compare survival differences in adult CF patients wi...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-016-9861-8
更新日期:2016-06-01 00:00:00
abstract:INTRODUCTION:Bronchopleural fistula is a rare but potentially fatal complication of pulmonary resections and proper management is essential for its resolution. In this study, we analyzed the incidence of fistula after pulmonary resection and reported data about endoscopic and conservative treatments of this complicatio...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-016-9841-z
更新日期:2016-04-01 00:00:00
abstract:INTRODUCTION:Prophylactic continuous positive airway pressure (CPAP) can prevent pulmonary adverse events following upper abdominal surgeries. The present meta-regression evaluates and quantifies the effect of degree/duration of (CPAP) on the incidence of postoperative pulmonary events. METHODS:Medical databases were ...
journal_title:Lung
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s00408-016-9855-6
更新日期:2016-04-01 00:00:00
abstract:INTRODUCTION:Sarcoidosis is a systemic granulomatous disease which predominantly affects the lungs, although granulomas can also involve all other organs, including the heart. Cardiac sarcoidosis (CS) may occur at any stage of the disease and may be the cause of sudden cardiac death, even in a previously asymptomatic p...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-015-9805-8
更新日期:2016-02-01 00:00:00
abstract::The practice of sedation dosing strategy in mechanically ventilated patient has a profound effect on cognitive function. We conducted a comprehensive review of outcome of sedation on mental health function in critically ill patients on mechanical ventilation in the intensive care unit (ICU). We specifically evaluated ...
journal_title:Lung
pub_type: 杂志文章,评审
doi:10.1007/s00408-015-9820-9
更新日期:2016-02-01 00:00:00
abstract:BACKGROUND:Asbestos is a carcinogen linked to malignant mesothelioma (MM) and lung cancer. Some gene aberrations related to asbestos exposure are recognized, but many associated mutations remain obscure. We performed exome sequencing to determine the association of previously known mutations (driver gene mutations) wit...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-015-9814-7
更新日期:2016-02-01 00:00:00
abstract::Respiratory virus infections leads to coughing, sneezing, and increases in reflex parasympathetic bronchoconstriction and secretions. These responses to viral infection are exclusively or largely secondary to changes in the function of the nervous system. For many with underlying airway pathologies such as asthma and ...
journal_title:Lung
pub_type: 杂志文章,评审
doi:10.1007/s00408-015-9832-5
更新日期:2016-02-01 00:00:00
abstract:PURPOSE:We aimed to determine the time, dose, and volume responses in a mouse pulmonary injury model following ablative dose focal irradiation (ADFIR) in order to better understand normal lung injury. METHODS AND MATERIALS:ADFIR was administered to the left lung of mice using a small animal micro-irradiator. Histopath...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-015-9825-4
更新日期:2016-02-01 00:00:00
abstract:BACKGROUND:There is very little evidence of the utility of the exhaled fraction of NO (FeNO) for the diagnosis of interstitial lung disease and nearly all of it is related with connective tissue disease. Some authors have suggested that in patients with hypersensitivity pneumonitis (HP), evolution to pulmonary fibrosis...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-015-9824-5
更新日期:2016-02-01 00:00:00
abstract:INTRODUCTION:Idiopathic pulmonary fibrosis (IPF) is a progressive and lethal fibrosing lung disease with a median survival of approximately 3 years after diagnosis. The only medical option to improve survival in IPF is lung transplantation (LTX). The purpose of this study was to evaluate trajectory data of IPF patients...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-015-9794-7
更新日期:2015-12-01 00:00:00
abstract:PURPOSE:The aim was to investigate whether maintenance therapy (MT) is sufficient or not to improve overall survival (OS) and progress-free survival (PFS) of advanced non-small cell lung cancer (NSCLC) patients. METHODS:Randomized controlled trials (RCTs) published between 1990 and 2013 were retrieved from PubMed, EMB...
journal_title:Lung
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s00408-015-9758-y
更新日期:2015-10-01 00:00:00
abstract::Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) is recognized as a preneoplastic condition by the World Health Organization. We reviewed our experience with 30 patients and performed a systematic review of the English literature to collect best evidence on the clinical features and disease cours...
journal_title:Lung
pub_type: 杂志文章,评审
doi:10.1007/s00408-015-9755-1
更新日期:2015-10-01 00:00:00
abstract:PURPOSE:Improving dyspnea and exercise performance are goals of COPD therapy. We tested the hypothesis that air current applied to the face would lessen dyspnea and improve exercise performance in moderate-severe COPD patients. METHODS:We recruited 10 COPD patients (5 men, age 62 ± 6 years, FEV1 0.93 ± 0.11 L (34 ± 3%...
journal_title:Lung
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00408-015-9780-0
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND:Tree-in-bud (TIB) is a radiologic pattern seen on high-resolution chest CT reflecting bronchiolar mucoid impaction occasionally with additional involvement of adjacent alveoli. Its microbiologic significance has not been systematically evaluated. OBJECTIVES:We aimed to establish the incidence of the TIB pat...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-015-9759-x
更新日期:2015-10-01 00:00:00
abstract:PURPOSE:The relationship between asthma and obesity is well established, although the pathophysiological mechanisms linking both diseases remain unknown. Adiponectin is a hormone secreted by adipose cells, plays a role in the modulation of inflammation and may be the key linking these two types of inflammation. METHOD...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-015-9793-8
更新日期:2015-10-01 00:00:00
abstract:PURPOSE:Exercising or doing physical activity in polluted air could expose a person to the adverse health effects of air pollution. This study aimed to compare the cardiovascular and hematologic indices following an incremental exercise test (shuttle run) under clean versus polluted air conditions. METHODS:Nineteen ma...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-014-9679-1
更新日期:2015-04-01 00:00:00
abstract:PURPOSE:Asthmatics are adversely affected by the presence of air pollutants, the concentrations of which can nowadays be measured. However, the utility of this information in clinical practice has not been defined in a group of asthmatics in stable condition. Our objective was to determine what impact the level of air ...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-015-9695-9
更新日期:2015-04-01 00:00:00
abstract:PURPOSE:Current guidelines recommend the use of low molecular weight heparin (LMWH) for most haemodynamically stable patients with pulmonary thromboembolism (PTE), however, it is not clear whether LMWH is preferable to unfractionated heparin (UFH) for the treatment of massive PTE. We aimed to compare the use of LMWH ve...
journal_title:Lung
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00408-014-9660-z
更新日期:2015-02-01 00:00:00
abstract:PURPOSE:Acute exacerbations (AE) in patients with COPD are associated with a decline in lung function, increased risk of hospitalization, and mortality. In this cross-sectional study we tested whether the level of objectively measured daily physical activity and exercise capacity are associated with the number of COPD ...
journal_title:Lung
pub_type: 杂志文章,多中心研究
doi:10.1007/s00408-014-9673-7
更新日期:2015-02-01 00:00:00
abstract:PURPOSE:Traditional inflammatory biomarkers are insufficient for the evaluation of bronchiolitis severity. Recent investigations have shown that the receptor for advanced glycation end product (RAGE) and its soluble isoforms (sRAGE) play a critical role in the pathogenesis of lung injury. Main objective was to assess t...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-014-9663-9
更新日期:2015-02-01 00:00:00
abstract:PURPOSE:Pulmonary hypertension (PH) due to COPD has dismal prognosis. We reviewed the long-term effect of PH-target therapy in severe PH-COPD. METHOD:Patients attending our PH-clinic were reviewed for PH-COPD receiving PH-target therapy. Baseline characteristics, death/transplantation until 2014, therapy, NYHA functio...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-014-9650-1
更新日期:2014-12-01 00:00:00
abstract:PURPOSE:Melanocortin 3 Receptor (MC3R) is one of the families of seven-transmembrane G-protein-coupled receptors, and a recent study showed that MCR3 promoter polymorphism was significantly associated with the susceptibility of tuberculosis (TB) in South African population. METHODS:We analyzed six MC3R polymorphisms t...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-014-9625-2
更新日期:2014-12-01 00:00:00
abstract:INTRODUCTION:Chronic obstructive pulmonary disease (COPD) is a major public health problem worldwide and is proved to be the number three cause of death in globally. The objective of this study was to explore the molecular mechanism of the progression of COPD. METHODS:Using the GSE1650 affymetrix microarray data acces...
journal_title:Lung
pub_type: 杂志文章,收录出版
doi:10.1007/s00408-014-9631-4
更新日期:2014-12-01 00:00:00
abstract::Accessory cardiac bronchus is a poorly recognized, usually asymptomatic, congenital abnormality of the bronchial tree. Recognition of bronchial anomalies is important since they are associated with clinical complications including recurrent episodes of infection, hemoptysis, and in some cases malignancy. ...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-014-9617-2
更新日期:2014-10-01 00:00:00
abstract::Overlap syndrome and represents a complex clinical condition in pulmonary medicine. We discuss in this letter factors related with mortality after long-term effects CPAP and key differences between hypercapnic versus hypoxemic overlap patients. ...
journal_title:Lung
pub_type: 评论,信件
doi:10.1007/s00408-014-9613-6
更新日期:2014-10-01 00:00:00
abstract:BACKGROUND:We previously demonstrated that the exposure to hyperbaric hyperoxia increased respiratory system elastance and both the "ohmic" and viscoelastic components of inspiratory resistances, probably because of increased oxygen tension toxic effects. We presently investigated the possible consequences of a single ...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-014-9576-7
更新日期:2014-08-01 00:00:00
abstract:BACKGROUND:Although lung transplantation is the only means of survival for patients with end-stage pulmonary disease, outcomes from this intervention are inferior to other solid organ transplants. The reason for the poor outcomes may be linked to an early reaction, such as primary graft dysfunction, and associated with...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-014-9588-3
更新日期:2014-08-01 00:00:00
abstract:INTRODUCTION:Living donor lobar lung transplantation (LDLLT) has been successfully used in select patient populations. MATERIALS AND METHODS:A 29-year-old male, who underwent bilateral LDLLT 12 years earlier with allografts donated by father and paternal uncle, developed bronchiolitis obliterans syndrome at distinctly...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-014-9560-2
更新日期:2014-06-01 00:00:00
abstract:PURPOSE:This study was designed to review outcomes of once- (QD) versus twice-daily (BID) radiotherapy (RT) for limited stage small-cell lung cancer (L-SCLC) treated at Dana-Farber Cancer Institute/Brigham and Women's Hospital. METHODS:We reviewed records for all patients with L-SCLC treated with radical chemoradiothe...
journal_title:Lung
pub_type: 杂志文章
doi:10.1007/s00408-013-9518-9
更新日期:2014-02-01 00:00:00